Type 2 Diabetes patients are more likely to develop acute pancreatitis compared to Diabetes-free people, reveals a study published in Diabetes Care on September 10. Dr. Antonio Gonzalez-Perez, of Centro Espanol de Investigacion Farmacoepidemiologica, Madrid, Spain, and colleagues, wrote, "The results of this study confirm the excess risk of acute pancreatitis associated with Type 2 Diabetes previously reported in other observational studies."
Study
Data from The Health Improvement Network database in the UK, between 1996 and 2006 were taken to study the risk of acute pancreatitis among patients with Type 2 Diabetes. The researchers performed a population-based case-control analysis in a cohort of 85,525 Type 2 Diabetes patients and 200,000 Diabetes-free subjects from the general population. They followed the patients for an average of 3.8 and 4.0 years, respectively.
Results
· A total of 419 cases of acute pancreatitis were identified, including 243 in the general population and 176 in the Diabetes cohort.
· The adjusted incidence rate ratio of acute pancreatitis in Diabetic patients compared to the general population was 1.77, but the magnitude of this association decreased when it was adjusted for multiple demographic and lifestyle factors (adjusted odds ratio 1.37).
· The use of insulin (adjusted OR 0.35) and long-term use of metformin (adjusted OR 0.50) were associated with a decreased risk of pancreatitis. Past use of sulphonylureas was associated with a significant risk increase (adjusted OR 2.58).
Comments from researchers
"Overall, when we analyzed the risk of pancreatitis among treated and not treated diabetic patients separately, we observed that the greatest risk appeared among those without anti-diabetic pharmacotherapy, who represent a quarter of our diabetic population."
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