The cause of Diabetes totally depends on its type. Type 1 Diabetes is partly inherited and then encouraged by certain infections some evidence pointing at Coxsackie B4 virus. However, even in those who have inherited the susceptibility, Type 1 Diabetes mellitus seems to require an environmental trigger. Type 2 Diabetes mainly results due to lifestyle factors and genetics.
Other Causes:
Genetic defects of β-cell Function
o Maturity onset diabetes of the young (MODY)
o Mitochondrial DNA mutations
Genetic defects in insulin processing or insulin action
o Defects in proinsulin conversion
o Insulin gene mutations
o Insulin receptor mutations
Exocrine Pancreatic Defects
o Chronic pancreatitis
o Pancreatectomy
o Pancreatic neoplasia
o Cystic fibrosis
o Hemochromatosis
o Fibrocalculous pancreatopathy
Endocrinopathies
o Growth hormone excess (acromegaly)
o Cushing syndrome
o Hyperthyroidism
o Pheochromocytoma
o Glucagonoma
Infections
o Cytomegalovirus infection
o Coxsackievirus B
Drugs
o Glucocorticoids
o Thyroid hormone
o β-adrenergic agonists
